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Clonazepam; About, Dosage, Side Effects, Drug Interactions, Alternatives
Clonazepam is a potent antiepileptic medication used to prevent and treat seizures. In addition, FDA has approved Clonazepam use for panic disorder with or without agoraphobia and recommended it in people undergoing alcohol withdrawal or suffering from sleep disorders.
The American Academy of Neurology guidelines mention using Clonazepam as a short-term treatment option for tardive dyskinesia ( a movement disorder characterized by uncontrollable, abnormal, and repetitive movements of the face, torso, or other body parts).
What is Clonazepam
Clonazepam, available under the brand names of Klonopin and Rivotril, is a tranquillizer of the benzodiazepine group with anticonvulsant, sedative, hypnotic, and anxiolytic properties that physicians use as a first-line treatment for seizures.
Studies have demonstrated its comparable safety and efficacy to other benzodiazepines for treating various anxiety disorders. Comparative studies between Clonazepam vs Lorazepam, another potent anxiolytic available under the brand name Ativan have shown the ability of Clonazepam to deal with a broader range of neuropsychiatric issues like seizures and panic disorders.
To achieve its therapeutic efficacy, Clonazepam acts as a positive allosteric modulator of the GABA-A receptors (A ligand of GABA receptors ). GABA is the principal inhibitory neurotransmitter in the cerebral cortex that maintains the inhibitory tone that counterbalances neuronal excitation.
Consequently, an increase in GABA levels inhibits the fast electric signalling associated with epilepsy. It changes how chlorine ions are transported in and out of the neurons to provide seizure-relief symptoms.
How to take Clonazepam?
Clonazepam is available in the immediate-release form in strengths of 0.5 mg, 1 mg, and 2 mg. You can even obtain it in an orally-disintegrable form in strengths of 0.125 mg, 0.25 mg, 0.5 mg, 1 mg, and 2 mg.
For seizure disorders, physicians advise 0.5 mg as a starting dose, followed by increasing it to Clonazepam 1mg strength based on the intensity of the problem and your tolerance levels.
For Sleep Behavior Disorders, health practitioners advise Clonazepam in strengths of 0.25-2 mg and counsel it to use thirty minutes before bedtime for a satisfactory sleep period.
In Tardive Dyskinesia conditions, the physician decides the strength of Clonazepam based on your response and tolerance to its use and discourages using it for more than three months.
Health experts advise using Clonazepam in individuals between 18-64 years and discourage using it in people younger or older than the required age limit.
But before you buy Clonazepam online, seek a doctor’s advice. They may advise a dosing modification or lower strength of Clonazepam in persons with systemic complications like liver or kidney disorders.
Are there any side effects?
Because of its benzodiazepine nature and impact on GABA receptors, the use of Clonazepam can result in side effects and adverse reactions when used incorrectly or for long periods. Some of the side effects are
- Increased saliva
- Lack of appetite
- Unusual tiredness or weakness
- Bladder pain
- Difficulty sleeping
If the side effects persist or increase in intensity, discontinue using the medicine and seek urgent medical attention.
Does Clonazepam have any drug interactions?
Some of the common drug interactions associated with Clonazepam are
- With ketoconazole
- With anticonvulsants like Phenytoin and Phenobarbital
- With opioid cough medications like Codeine syrup
- With sleeping medications like Zolpidem
Inform your practitioner about your drug history to avoid possible drug interactions from using them with Clonazepam.
What are some alternatives to Clonazepam?
Sometimes Clonazepam may not suit your requirements or tolerance levels. In such cases, the physician will prescribe alternative treatment options like
- Effexor XR
Your physician will decide the best alternative based on your allergic status and history of drug interactions. Discuss with your physician any doubts that you may have regarding the dose and strength of alternative treatment methods.
1. Can I take Clonazepam with Alcohol?
You should never use Clonazepam with Alcohol as it may enhance each other’s effects and result in symptoms of overdose. You should wait for at least five days after discontinuing Clonazepam till its effects are completely eliminated from your system before intaking alcohol.
2. Can I take Clonazepam during Pregnancy?
You can take Clonazepam during pregnancy, especially if you need it to control your seizures. Inform your health care pregnant if you are pregnant or planning to get pregnant during the initial treatment period so they can lower the Clonazepam dose or provide an alternative that is safe for the fetus.
3. Can clonazepam be used for long-term treatment?
Clonazepam is generally prescribed for short-term use due to the risk of dependence and tolerance. Long-term use should be carefully monitored by a healthcare provider.
4. Can clonazepam be used as a sleep aid?
Clonazepam may be prescribed for short-term use in treating sleep disorders, particularly when associated with anxiety. However, it is not recommended as a long-term sleep aid.
5. Can clonazepam be addictive?
Clonazepam carries a potential risk for dependence and addiction, especially if used for an extended period or at high doses. It is important to use the medication as prescribed and under the guidance of a healthcare provider.
6. Can I take clonazepam with other medications?
Clonazepam can interact with certain medications, including antidepressants and sedatives. It is important to inform your healthcare provider about all the medications you are taking to avoid potential interactions.
7. Where to buy Clonazepam?
Clonazepam is a scheduled medication and is not readily available over the counter. You need to obtain a prescription from a licensed physician to procure the medication from a Mexican Farmapram. Before you buy Clonazepam online, ensure that the website you have selected is authentic and has a good reputation.
Clonazepam is a powerful drug. But it is prone to misuse because of its effect on GABA reactions. Discuss with your health provider regarding its effects and risks to using it safely for your seizures, sleep, and panic disorders.